The great regulator
نویسنده
چکیده
the discovery of rNa interference (rNai) in 1998 sparked a revolution in rNa research (Fire et al, 1998). it also triggered a surge of investment from biotechnology companies and major pharmaceutical companies to develop new drugs and therapies that exploit this new mechanism of gene regulation. the commercial interest intensified in 2006 after andrew Fire and craig Mello received the Nobel prize for their discovery of rNai. almost immediately, Merck invested uS$1.1 billion to acquire Sirna therapeutics, which had several rNai-based drugs in the pipeline or in clinical trials. this quickly persuaded other pharmaceutical companies to pile in, including roche, pfizer and Novartis. Since then, however, impatience with the rate of progress and the side effects and delivery problems of some rNai-based therapeutics has caused roche and pfizer to divest their rNai investments, and Novartis to reduce its commitment.
منابع مشابه
Survey of accessory gene regulator (agr) groups and TSST-1 encoding gene (tst) in Staphylococcus aureus isolated from ewes with mastitis in the northwest of Iran
Accessory gene regulator (agr locus) is a global regulator of many virulence gene expressions inStaphylococcus aureus. Four interference classes related to genetic polymorphisms in the agr locus have sofar been described. In the present study, the agr locus specificity groups were studied within a total of 43 S.aureus isolates which were isolated from ewes with mastitis in three regions in the ...
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